The Long-term Effect of Remote Ischemic Conditioning on Main Organs in ASVCD Patients With Very High Risks

Inclusion Criteria

• •Age over 40 years
• •Two or more prior major ASCVD events; OR one documented major ASCVD event with two or more of the following risk factors
• •signed informed consent
• •Note： Definition of Major ASCVD Events:
• •A. Acute coronary syndrome within the past year. B. History of myocardial infarction (not part of a new acute coronary syndrome episode).
• •C. Ischemic stroke or history of ischemic stroke. D. Symptomatic peripheral artery disease, defined as intermittent claudication with an ankle-brachial index (ABI) \< 0.85, or prior limb revascularization or amputation.
• •Risk factors:
• •1. Age ≥65 y
• •2. Heterozygous familial hypercholesterolemia
• •3. History of prior coronary artery bypass surgery or percutaneous coronary intervention outside of the major
• •4. ASCVD event(s)
• •5. Diabetes mellitus
• •6. Hypertension
• •7. CKD (eGFR 15-59 mL/min/1.73 m2)
• •8. Current smoking
• •9. Persistently elevated LDL-C (LDL-C ≥100 mg/dL \[≥2.6 mmol/L\]) despite maximally tolerated statin therapy and ezetimibe
• •10. History of congestive HF