A Phase III Randomised Control Clinical Trial of Radiotherapy With Radiosensitisation Versus Intravesical Bacillus Calmette-Guerin Therapy for High-risk Non-muscle Invasive Bladder Cancer.

Exclusion Criteria

• •MDT selected patients with HR-NMIBC who are deemed best suited for primary cystectomy (patients that have had this treatment recommendation but then decline cystectomy remain eligible for TRAIN)
• •Previous radiotherapy to the pelvis
• •Previous intravesical therapy
• •Poor bladder function (IPSS \>16)
• •A recent or current other cancer. Current non-melanoma skin cancer, cervical carcinoma in situ or localized prostate cancer not requiring current treatment are permissible, as is a history of a separate other malignancy having completed all active treatment ≥2 years previously and without evidence of relapse
• •Pre-existing medical conditions that preclude treatment options in either trial arm
• •Patient currently recruited to another interventional trial or participation within an interventional clinical trial within 3 months of the point of registration within TRAIN.
• •Pregnant or breast-feeding
• •Not able to use appropriate adequate effective contraception during and for 3 months after the study