Finding studies
Finding studies
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Henan Province Cancer Hospital Ethics Committee Henan Province Cancer Hospital Ethics Committee
CONTACT
Lead
Henan Cancer Hospital
This study is a single-arm, open-label, dose-escalation and dose-expansion phase Ib/II clinical trial aimed at evaluating the safety, tolerability, biological distribution characteristics, and preliminary efficacy of recombinant human nsIL12 oncolytic adenovirus injection (BioTTT001) in patients with recurrent/progressive non-small cell lung cancer with meningeal metastases. The study is divided into two phases: the phase Ib dose-escalation .The dose escalation phase establishes three dosage groups, namely 1.0×10\^9 VP, 5.0×10\^9 VP, and 1.0×10\^10 VP and the phase II dose-expansion.
Age
18–70
Sex
ALL
Healthy volunteers
Not accepted