Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Tianjin Medical University Cancer Institute and Hospital
With
Shaanxi Provincial Cancer Hospital
The First Affiliated Hospital of Henan University of Science and Technology
Shanxi Bethune Hospital
Tianjin Cancer Hospital Airport Hospital
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. The patient is at least 18 years of age;
2. The patient has a histologically or cytologically confirmed diagnosis of breast cancer;
3. The patient is receiving full-dose trastuzumab deruxtecan (T-DXd) monoclonal antibody therapy for the first time;
4. The patient has an Eastern Cooperative Oncology Group (ECOG) performance status score of 2 or lower;
5. The patient voluntarily agrees to comply fully with the study protocol requirements and has provided written informed consent.
You may not be if
1. The patient is currently taking medications that may interfere with the assessment of nausea or vomiting, including but not limited to other 5-HT3 receptor antagonists, NK1 receptor antagonists, psychotropic agents, or opioid analgesics;
2. The investigator determines that the patient's nausea or vomiting is highly likely attributable to anti-tumor treatments not involving antibody-drug conjugate (ADC) therapy;
3. The patient is deemed unsuitable for glucocorticoid or progesterone use;
4. The patient has a history of hypersensitivity to netupitant, palonosetron, or any excipient in the capsule formulation;
5. The patient has significant gastrointestinal conditions affecting oral drug absorption, such as dysphagia, chronic diarrhea, or intestinal obstruction;
6. The patient has a severe psychiatric disorder or difficulties understanding the study procedures, completing questionnaires, or communicating effectively in Chinese;
7. The investigator identifies any other condition that may compromise the conduct of the clinical study or the interpretation of its results.
Clareo Health | A Study on Nausea and Vomiting Caused by T-DXd in Breast Cancer Patients
