Anti-inflammatory Effects and Clinical Efficacy of Topical Thealoz Total Eye Drops in Patients With Chronic Dry Eye Disease and Associated Ocular Surface Inflammation

Exclusion Criteria

• •\- Best far corrected visual acuity \< 1/10
• •Severe Dry Eye associated with:
• •Eyelid malposition
• •Stevens Johnson Syndrome
• •Corneal dystrophy
• •Ocular neoplasia
• •Filamentous keratitis
• •Corneal neovascularisation
• •Orbital radiotherapy
• •Dry eye related to GVHD
• •History of any of the following within last 3 months:
• •Systemic treatment of dry eye
• •Systemic treatment of MGD
• •Isotretinoïde,
• •Cyclosporine,
• •Tacrolimus, Siromilus, Pimecrolimus
• •Punctual plugs
• •History of any of the following within previous six months:
• •ocular trauma
• •ocular infection, Ocular allergy
• •History of any of the following within last 12 months:
• •inflammatory corneal ulcer
• •Herpetic eye infection or uveitis
• •Ocular surgery
• •\- Known hypersensitivity to any of the components of the medical device under investigation or other study medication
• •Pregnant or breast-feeding woman.
• •Woman of childbearing potential (neither menopausal, nor hysterectomized, nor sterilized) not using effective contraception (i.e. hormonal contraceptives, intra-uterine device, contraceptive implant or condoms)
• •\- Inability of patient to understand the investigation procedures and thus inability to give valid, informed consent.