Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study

Exclusion Criteria

• •1. History of psychotic or bipolar disorder or depression with psychotic features;
• •2. Significant borderline personality disorder;
• •3. Significant comorbid obsessive-compulsive or post-traumatic stress:
• •4. Current moderate or severe substance use disorder or demonstrating signs of acute substance withdrawal;
• •5. Clinically significant suicidality disorder;
• •6. Chronic depression (defined as of over 5 years duration);
• •7. Pregnancy or lactation, lack of adequate birth control in women of childbearing age;
• •8. History of significant neurologic disease, including dementia, Parkinson's or Huntington's disease, brain tumor, seizure disorder, subdural hematoma, multiple sclerosis, or history of significant head trauma with persistent symptoms;
• •9. Unstable medical illness;
• •10. Contraindication to receiving tDCS (e.g., ferromagnetic implant, history of seizure, known brain lesion);
• •11. History of TMS (greater than 15 sessions) without a clinically meaningful response.; History of ketamine (greater than 4 sessions) without a clinically meaningful response;
• •12. Require a benzodiazepine with a dose \> lorazepam 2 mg/day;
• •13. dermatological conditions contraindicating tDCS;
• •14. Non-correctable sensory impairments;
• •15. Inability to consent or participate as an outpatient