A Drug-Drug Interaction Study of Denifanstat and Resmetirom in Healthy Adult Participants

Exclusion Criteria

• •Significant history or clinical manifestation of any metabolic, allergic, dermatological, hepatic, renal, hematological, pulmonary, cardiovascular, gastrointestinal, neurological, respiratory, endocrine, or psychiatric disorder.
• •History of stomach or intestinal surgery or resection that would potentially alter absorption and/or excretion of orally administered drugs (cholecystectomy will not be allowed; uncomplicated appendectomy and hernia repair will be allowed).
• •Presence of any other condition (including surgery) known to interfere with the absorption, distribution, metabolism, or excretion of medicines.
• •History or presence of hepatobiliary or thyroid-related disease.
• •Significant change (approximately 10% increase or decrease) in weight within 3 months prior to first dosing in the opinion of the PI or designee.
• •History of alcoholism or drug/chemical abuse within 2 years prior to check-in.
• •Positive results for HIV, HBsAg, or HCV at the screening visit.
• •Poor peripheral venous access.