First-in-Human Study of ALN-SNCA in Adult Participants With Early Parkinson's Disease (PD)

Exclusion Criteria

• •1. Medical history indicating a Parkinsonian syndrome other than Parkinson's disease, as defined in the protocol
• •2. Clinically significant cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, hematological, psychiatric or neurological disease (excluding Parkinson's disease) that, as assessed by the investigator, may confound the results of the study or pose an additional risk to the participant during study participation
• •3. Medical history of brain or spinal disease/injury that would interfere with the Lumbar Puncture (LP) procedure or CSF circulation, as defined in the protocol
• •4. Any contraindications to undergo a brain Magnetic Resonance Imaging (MRI)
• •5. An established allergy or intolerance to lidocaine anesthetic, as defined in the protocol
• •6. History of intolerance to Intrathecal (IT) injection(s)
• •7. Current history of bleeding diatheses that would increase risk of bleeding upon LP
• •8. Has undergone gene therapy, cell therapy or surgical treatment, including deep brain stimulation, for Parkinson's disease