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COMPLETEDPhase 2NCT07212842

Methylene Blue-Enhanced Ultrafiltration Improves Outcomes After Cardiopulmonary Bypass

Introduction: Fluid overload and systemic inflammation are major contributors to postoperative complications in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Objective: To eva...

Lead sponsor: University of Sao Paulo•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

University of Sao Paulo

Age

20 - 60 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Clinical diagnosis of cardiac disease requiring surgery with cardiopulmonary bypass (CPB)
•Age ≥ 18 years
•Ability to provide informed consent

Exclusion Criteria

•Chronic renal failure
•Recent cardiac catheterization within the past month
•Planned cardiac surgeries with an estimated CPB time of less than 60 minutes
•Aortic surgery
•Significantly impaired hepatic function

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: October 8, 2025Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE2

Enrollment124

Start dateApr 2021

Last updatedOct 8, 2025

Condition

Cardiopulmonary Bypass Surgery Aortic Valve Surgery Mitral Valve Surgery

Locations shown

University of São Paulo Medical School in Ribeirão Preto

Ribeirão Preto, São Paulo

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 8, 2025Data synced to Clareo: July 13, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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