Baricitinib Curative Repression of HIV-1

Exclusion Criteria

• •\< 18 years of age or \> 70 years of age
• •Pregnancy or breastfeeding, as determined by a blood pregnancy test
• •History of AIDS-defining illness, except for recurrent pneumonia.
• •History of progressive multifocal leukoencephalopathy or clinically significant HIV-associated neurocognitive disease.
• •Untreated latent tuberculosis infection (which will be screened for before entry). If there is a prior positive test, the test does not need to be repeated at screening.
• •History of use of any immunomodulatory medications within 6 months before enrollment, including systemic corticosteroids (\>14 days), immunosuppressants, anti-cancer, interleukins, systemic interferons, systemic chemotherapy, or other medications that the site investigator feels could have an immunomodulatory effect.
• •History of deep venous thrombosis
• •Cardiovascular disease (Coronary artery disease or history of myocardial infarction, Congestive heart failure with left ventricular ejection fraction ≤40% per American Heart Association guidelines, history of stroke)
• •History of HIV-associated malignancy, including Kaposi's sarcoma, or any lymphoma/leukemia or virus-associated cancers. Active or recent non-HIV-associated malignancy requiring systemic chemotherapy or surgery in the preceding 36 months
• •Major surgery within 8 weeks before screening, or will require major surgery during the study
• •Current or recent (\<4 weeks before screening) clinically serious viral (including COVID-19), bacterial, fungal, or parasitic infection or any other active or recent infection. History of untreated syphilis infection. If a rapid plasma reagin (RPR) test was negative in the 3 months before screening, then an RPR is not needed at screening
• •Symptomatic herpes simplex at the time of screening.
• •Symptomatic herpes zoster infection within 12 weeks before screening.
• •History of disseminated/complicated herpes zoster (for example, ophthalmic zoster or central nervous system (CNS) involvement).
• •Positive test for hepatitis B virus (HBV)