Transcatheter Edge-to-Edge Repair In Moderate and Exertional-Induced Severe MR (TIMER)

Exclusion Criteria

• •1. Stage D heart failure per ACC/AHA guidelines with hemodynamic instability or cardiogenic shock
• •2. Untreated symptomatic coronary artery disease requiring revascularization
• •3. Chronic obstructive pulmonary disease (COPD) requiring continuous oxygen therapy or long-term corticosteroids therapy
• •4. Severe pulmonary hypertension or moderate-to-severe right ventricular dysfunction
• •5. Aortic or tricuspid valve disease requiring surgical or transcatheter intervention
• •6. Life expectancy \<12 months