International Study on Treatment of Liver (HCC) Patients With IRE

Exclusion Criteria

• •General:
• •Patients involved in other research studies.
• •Patients under the age of 18 years.
• •Inability to give informed consent.
• •Patients who are pregnant.
• •Child-Pugh B or C.
• •Patients with an ECOG status of \> 2 at time of recruitment.
• •Rockwood Frailty Score \> 3
• •Impaired renal function (serum creatinine \> 150 µmol/L)
• •Accepted exclusions to IRE from consensus criteria including:
• •Platelet count \< 50x109 U/L.
• •International normalised ratio (INR) for blood clotting \> 1.7.
• •Prior hepatic tumour ablation.
• •Cardiovascular fitness related exclusions:
• •History of ventricular arrhythmia.
• •Implanted pacemaker or defibrillator.
• •Congestive cardiac failure NYHA Class ≥ 3.
• •Tumour-related exclusions:
• •Tumour ≥ 3 cm in size.
• •Extrahepatic metastatic disease.
• •Jaundice (serum bilirubin \> 30 µmol/L).
• •MDT recommends use of thermal ablation for any given lesion.