A Pharmacokinetic Study of SHR8554 Injection in the Population With Renal Insufficiency and Healthy Participants

Exclusion Criteria

• •1. History of clinically significant allergies, known allergy to SHR8554, or any other structural analogs;
• •2. Subjects with positive tests for infectious diseases;
• •3. Pregnancy or lactation women, or a fertility male or female is not willing to contraception during test;
• •4. Unable to tolerate venipunctures or have a history of fainting needles and blood;
• •5. Historic abuse of alcoholic beverages;
• •6. Smoke ≥ 10 cigarettes per day within 3 months prior to the study;
• •7. History of drug abuse;
• •8. Diseases with abnormal clinical manifestations that occurred before screening or are currently occurring and need to be excluded for normal renal function group;
• •9. Vital signs, physical examination, 12-lead electrocardiogram, or laboratory examination deemed clinically significant by the investigator for normal renal function group;
• •10. History of renal transplantation and/or requirement for renal dialysis treatment during the study period for severe renal function group;
• •11. Urinary incontinence or anuria (e.g., \< 100 mL/day) for severe renal function group;
• •12. Other reasons that the investigator consider it inappropriate to participate in the trial.