Efficacy and Safety of 14-Day Vonoprazan-Based Dual Therapy Versus Quadruple Therapy for Helicobacter Pylori Eradication: A Multicentre, Non-Inferiority Randomized Controlled Trial

Exclusion Criteria

• •1. Severe underlying conditions, such as hepatic insufficiency, renal insufficiency, malignant tumours
• •2. Active gastrointestinal bleeding
• •3. History of upper gastrointestinal surgery
• •4. History of drug hypersensitivity
• •5. Use of bismuth compounds or antibiotics within the past 4 weeks, or acid-suppressing agents within the past 2 weeks
• •6. Pregnant or lactating women
• •7. Presence of other risk-increasing behaviours such as alcohol abuse or illicit drug use
• •8. Individuals unable or unwilling to provide informed consent