Epicardial Adipose Tissue Composition and Heart Failure With Preserved Ejection Fraction

Exclusion Criteria

• •• Previously or currently reduced EF (\<50%), including heart transplant; (2) Obstructive un-revascularized coronary disease by coronary CT or invasive coronary angiography;
• •* MI/PCI/CABG within the past 6 months;
• •* Untreated severe stenotic or regurgitant valvular disease;
• •* Infiltrative cardiomyopathy (Fabry/HCM/sarcoid/amyloid, etc);
• •* Myocarditis;
• •* Claustrophobia/inability to tolerate MRI;
• •* Implants that are a contraindication for MRI or may negatively impact image quality (e.g. pacemakers and ICDs);
• •* Active systemic inflammatory disorder;
• •* Atrial fibrillation with rapid ventricular response at time of study; and
• •* Hemodynamic instability
• •* Pregnancy
• •* Prisoners
• •* Inability to provide informed consent
• •allergy to gadolinium-based contrast agents
• •Acute kidney injury
• •Estimated glomerular filtration rate (eGFR) \< 30 mL/min/1.73 m²
• •Hepatorenal syndrome
• •History of liver transplant
• •High-grade atrioventricular (AV) block
• •Active asthma exacerbation
• •Known allergy to vasodilator agents
• •Recent seizure