Subphenotype- and Complication-guided Adjunctive Fosfomycin Therapy for Staphylococcus Aureus Bacteraemia

Exclusion Criteria

• •Polymicrobial bacteraemia
• •Severe clinical status with expected survival \< 24 hours
• •Severe liver disease with Child-Pugh score class C
• •Diagnosis of prosthetic infective endocarditis
• •Allergy or known resistance to study drugs
• •Pregnancy at the time of inclusion
• •Inclusion in another clinical trial
• •Diagnosis of MRSA pneumonia
• •Prior history of eosinophilic pneumonia
• •Use of additional antibiotic therapy with microbiological activity against MRSA
• •Prior history of myasthenia gravis
• •Acute SARS-CoV2 infection