A Study of DZD8586 Combination in CLL/SLL (TAI-SHAN10)

Exclusion Criteria

• •1. Any of previous or current treatment prohibited by protocol.
• •2. Any unresolved \> grade 1 drug-related adverse events.
• •3. Known or suspected Richter's transformation, or prolymphocytic leukemia.
• •4. CNS involvement.
• •5. Active infection.
• •6. Any of severe cardiac or pulmonary abnormalities.
• •7. Poorly controlled autoimmune anemia or autoimmune thrombocytopenia.
• •8. Poorly controlled gastrointestinal disorder, inadequate absorption of medication or other systemic diseases.
• •9. Prior malignancy within the past 3 years.
• •10. Known allergy to study drugs, any of the ingredients of the study drugs, or xanthine oxidase inhibitors or rasburicase.