Clearly defined clinical staging: including imaging or pathologically confirmed metastatic colorectal cancer (stage M1) and colorectal cancer without distant metastasis (stage M0)
Expected survival ≥ 3 months
Voluntary participation and signed informed consent
You may not be if
Use of probiotics, antibiotics, or immunosuppressive agents within 1 month before surgery
Preoperative complete intestinal obstruction or gastrointestinal perforation
Intraoperative gastrointestinal perforation or tumor rupture
Previous history of gastrointestinal surgery (excluding colorectal cancer surgery, appendectomy, and cholecystectomy) or concurrent severe gastrointestinal diseases such as inflammatory bowel disease
Concurrent active systemic immune or infectious diseases, including severe allergies, rheumatoid arthritis, systemic lupus erythematosus, viral hepatitis, acquired immunodeficiency syndrome, etc.
Concurrent unhealed primary malignant tumors
Severe organ dysfunction or failure
Other conditions deemed unsuitable for this study by the investigator
Clareo Health | Comprehensive Analysis of Gut Microbiota Signatures in Metastatic Colorectal Cancer
