Accelerated TMS for MDD

Exclusion Criteria

• •1. Participants satisfy any one or more of the contraindications for TMS per current treatment guidelines as determined by the PI
• •2. Total MADRS score of \< 20 or PHQ-score \<10 at the screen or baseline visits
• •3. Current diagnosis of substance use disorder (Abuse or Dependence, as defined by DSM-V-TR), with the exception of nicotine dependence
• •4. Displaying symptoms of substance withdrawal
• •5. History of schizophrenia or schizoaffective disorders, or any history of psychotic symptoms in the current or previous depressive episodes
• •6. Any disorder which at screening is clinically predominant to their MDD or has been predominant to their MDD at any time within six months prior to screening
• •7. Has a clinically significant abnormality on the screening examination that might affect safety, study participation, or confound interpretation of study results
• •8. Participation in any clinical trial with an investigational drug or device within the past month or concurrent to study participation
• •9. History of non-response to TMS or ECT
• •10. History of any implanted device or psychosurgery for depression
• •11. PI opinion: Considered at significant risk for suicide during the course of the study
• •12. Have any medical or psychological condition, that in the opinion of the referring psychiatrist or investigator, would prevent the participant from completing the study, put the participant at unacceptable risk or could interfere with study assessments or integrity of the data