The body responds to different stresses by releasing factors in the blood and fluids in response to stressors like injury, surgery or certain treatments. Some of these factors help heal and some make the injury and body swell (inflammation). In this study we want to see if the intervention of withdrawing fluid the knee or the addition of an enriched healing factor called platelet rich plasma (PRP) injected in the knee influences the body to produce healing factors in the knee joint fluid.
Age
18–50
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age 18 - 50
English-speaking
Clinical evidence of ACL rupture with swelling
Participant must be undergoing ACL reconstruction surgery
You may not be if
Age \<18 or \>50
Presentation \>3 weeks after initial injury
Previous traumatic ipsilateral (same side) knee injury consistent with chronic ACL tear or prior ACL surgery
\> Kellgren-Lawrence grade 2 changes on preoperative x-ray
History of hemophilia or inflammatory arthropathy (e.g., rheumatoid arthritis)
Clareo Health | Synovial Fluid Withdrawal or PRP Injection For Acute ACL Tears and Cytokines
