Sleep and Physical Activity in Patient and Caregiver Dyads Following Allogeneic Hematopoietic Cell Transplantation

Primary Objectives 2.1 Primary Objectives for the Entire Sample (N = 43 Dyads) * Assess the feasibility and acceptability of obtaining objective sleep and physical activity measures in participants receiving allogeneic HCT and their caregivers during hospitalization (T2), and after discharge (T3) using Fitbits. * Feasibility will be determined by the percentage of participants and caregivers who wear the Fitbit Inspire 3 for sleep and physical activity data at T2, and T3. For the purposes of this study, if ≥70% of participants and caregivers will wear the Fitbit for 5 of 7 nights for sleep data and at least 10 hours during waking hours for 5 of 7 days for physical activity data at both data collection periods, the study will be determined to be feasible. Feasibility will be reported for participants and caregivers separately and will include the percentage of eligible participants who are approached, agree to participate, and complete research activities. 2.1.1 Primary Objectives for Subgroup (n = 10 Dyads) • Feasibility for the subgroup of 10 dyads will be determined by the percentage of patients and caregivers who wear the Fitbit for sleep and physical activity data from T3 to T4 (6week period after hospital discharge). For the purposes of this study, if ≥70% of patients and caregivers wear the Fitbit for 29 of 42 nights for sleep data and at least 10 hours during waking hours for 29 of 42 days for physical activity data at T4, the study will be determined to be feasible. Feasibility will be reported for patients and caregivers separately and will include the percentage of eligible participants who are approached, agree to participate, and complete research activities. Secondary Objectives 2.2 Secondary Objectives for the Entire Sample (N = 43 Dyads) * Examine trends in objectively measured sleep, physical activity, and frailty, and participant-reported sleep disturbance, sleep-related impairment, anxiety, depression, fatigue, cancer treatment distress, and quality of life in allogeneic HCT participants and their caregivers during hospitalization (T2), and after discharge (T3). * Hypothesis 1: HCT participants will demonstrate improvements in objectively measured sleep, physical activity, and frailty, and participant-reported sleep disturbance, sleep-related impairment, anxiety, depression, fatigue, and cancer treatment distress from T2 to T3. * Compare objectively measured sleep and physical activity, and participant-reported sleep disturbance, sleep-related impairment, anxiety, depression, fatigue, cancer treatment distress, and quality of life between allogeneic HCT participants and their caregivers during hospitalization (T2), and after discharge (T3). * Hypothesis: HCT participants will demonstrate significant improvements compared to their caregivers in objectively measured sleep and physical activity, and patient-reported sleep disturbance, sleep-related impairment, anxiety, depression, fatigue, cancer treatment distress, and quality of life. 2.2.1 Secondary Objectives for Subgroup (n = 10 Dyads) Examine trends in objectively measured sleep, physical activity, and frailty, and participant-reported sleep disturbance, sleep-related impairment, anxiety, depression, fatigue, cancer treatment distress, and quality of life in allogeneic HCT patients (n = 10) and their caregivers (n = 10) one week after hospital discharge (T3) and six weeks after hospital discharge (T4). • Hypothesis 1: HCT patients will demonstrate improvements in objectively measured sleep, physical activity, and frailty, and participant-reported sleep disturbance, sleep-related impairment, anxiety, depression, fatigue, cancer treatment distress, and quality of life from T3 to T4, reflecting the expecting recovery. • Hypothesis 2: Caregivers will demonstrate increases in objectively measured sleep, physical activity, and frailty and participant-reported sleep disturbance, sleep-related impairment, anxiety, depression, fatigue, and cancer treatment distress from T3 to T4. Compare objectively measured sleep and physical activity, and participant-reported sleep disturbance, sleep-related impairment, anxiety, depression, fatigue, cancer treatment distress, and quality of life between allogeneic HCT patients (n = 10) and their caregivers (n = 10) after discharge (T3) and six weeks after hospital discharge (T4). • Hypothesis: HCT patients will demonstrate significant improvements compared to their caregivers in objectively measured sleep and physical activity, and patient-reported sleep disturbance, sleep-related impairment, anxiety, depression, fatigue, cancer treatment distress, and quality of life at T3 and no differences between groups at T4.