Second Affiliated Hospital, Zhejiang University, School of Medicine
The First Affiliated Hospital of Guangzhou Medical University
Shanxi Bethune Hospital
Henan Provincial People's Hospital
First Hospital of China Medical University
China-Japan Friendship Hospital
Beijing Tiantan Hospital
Second Xiangya Hospital of Central South University
Ruijin Hospital
Age
18–80
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age ≥18 years, and \<80 years with a definite diagnosis of asthma for at least 6 months
Patients met the 2024 GINA criteria for severe asthma, which was defined as "uncontrolled" asthma (frequent asthma symptoms, or frequent acute exacerbations) despite high-dose inhaled corticosteroids (ICS) plus long-acting β2-receptor antagonists (LABAs), or worsening of symptoms after slight tapering of high-dose therapy.
They were willing to accept multi-disciplinary and multi-dimensional evaluation and signed informed consent
Informed consent was obtained and patients were able to participate in the study and 6-month follow-up according to the protocol
You may not be if
The presence of numerous other lung tissue destructive diseases, such as severe bronchiectasis or pulmonary tuberculosis.
Chest surgery or abdominal surgery in the past 3 months
Eye surgery had been performed within the past 3 months
Myocardial infarction within the previous 3 months
Anti-tuberculosis treatment is ongoing
Women who are pregnant and lactating
Macrolide use within 4 weeks before the screening period
Treatment with anti-ige, anti-IL-5, or anti-IL-5R within 4 weeks before the screening period
Inhaled ICS+LABA+ long-acting anticholinergic agent (LAMA) for 4 weeks prior to the screening period 4. Allergy to macrolides
QTc interval prolongation \>480ms
Taking medications that interact with azithromycin, causing QTc prolongation or existing ECG abnormalities, may lead to arrhythmia
Clareo Health | The Study About the Identification of Treatable Traits of Severe Asthma and the Construction of Personalized Treatment System
