Real World Stage II-III NSCLC Patients Receiving Neoadjuvant Chemo-immunotherapy and no Surgical Resection

1. Participating centers will secure an ethics and administrative approval for retrospective collection of clinical data. 2. Relevant patients will be identified from the working database of each center, data will be collected locally, deidentified and collected centrally. 3. Where required, patients will be requested to provide informed consent for the participation in the study. 4. Data collected will include 1. Demographics (age, sex) 2. Patients' characteristics (smoking status, co-morbidities, ECOG-PS, weight loss) 3. Tumor characteristics (histology, molecular tests, specific test results, clinical stage). 4. Staging procedures done (CT, PET-CT, brain MRI, EBUS, mediastinoscopy) 5. Neoadjuvant treatment (regimen, number of cycles, dose reductions, delays). 6. Reason for surgery cancellation; to be categorized according to the following options: i. iRAE, ii. non-immune-related AEs, iii. molecular test result, iv. re-staging result showing lack of mediastinal clearing, v. distant disease progression, vi. local progression leading to patient becoming not-resectable, vii. re-assessment of patient as not-resectable (without a significant change in the tumor), viii. change in the patient condition making the patient not-operable. 5. Data will be entered to an eCRF, anonymized and collected centrally at Sheba MC. 6. Analysis of the data according to the statistical analysis plan. Inclusion criteria: 1. Stage II-III NSCLC patient, based on clinical staging. 2. Treated by a chemo-immunotherapy regimen defined as neoadjuvant treatment, for at least one cycle of treatment. 3. No surgery was performed for at least six months from initiation of the neoadjuvant treatment. 4. Availability of data about reasons for surgery cancellation and clinical follow up. 5. Patient's consent for data collection (or waiver of the need for consent by the local ethics committee). 6. At least 6 mo of follow up after initiation of neoadjuvant treatment. Statistical analysis plan: Data will be analyzed based on the reason defined for surgery cancellation. Analyses will be descriptive, reporting mean, median, 95% C.I. as relevant. Time-to-event measures will be estimated by Kaplan-Meier method. Comparisons between groups will be done in a descriptive manner, using t-test, Chi-square and log-rank test as appropriate. Ethics: Each participating center will receive approval of the local IRB. Unless waived, each participating patient will sign an informed consent form prior to any study procedure. Patient data confidentiality: No identifying information regarding participating patients will leave each of the centers. Participants will be given a study code, the key connecting the code to the patients' identity will be kept at each participating site secured as per local regulations of each site. Data transfer: clinical data files (excel or equivalent) will be transferred to Sheba MC by email. Data sharing: At the end of the study, the clinical data will be made available to requesting researchers following review of requests.