Amy Hoang

CONTACT

Laura Sarmiento

CONTACT

Lead Sponsor

Cedars-Sinai Medical Center

Collaborators

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•1. Patients 18 years of age and older of any sex.
•2. Have a primary diagnosis, or a high clinical suspicion, of gastroesophageal adenocarcinoma based on CT (computed tomography)/PET (positron emission tomography) or other imaging (Cohort 1) or diagnosis of appendiceal adenocarcinoma with a high clinical suspicion of peritoneal carcinomatosis (Cohort 2).
•3. Have an indication for surgical intervention for gastroesophageal tumor resection or diagnostic laparoscopy for assessment of peritoneal disease burden.
•4. Willingness to stop the use of folate, folic acid, or folate-containing supplements within 48 hours before administration of CYTALUX.
•5. Willingness of research participant to give written informed consent.

•1. Any medical condition that in the opinion of the investigators could potentially jeopardize the safety of the subject.
•2. History of anaphylactic reactions to products containing indocyanine green for near infrared imaging. Subjects with a medical history of 'idiopathic anaphylaxis' will require evaluation.
•3. History of allergy to any of the components of CYTALUX™ (pafolacianine) injection.
•4. Presence of any psychological, familial, sociological condition or geographical challenges potentially hampering compliance with the study protocol or follow-up schedule.
•5. Known sensitivity to fluorescent light.
•6. Women of childbearing potential who are pregnant or plan to become pregnant during the study.