Studying Flavors and Cooling Agents in Oral Nicotine Pouches to Understand User Preferences

PRIMARY OBJECTIVES: I. Evaluate the individual and joint effects of menthol flavors and WS-3 on appeal of ONPs. II. Test the individual and joint effects of menthol flavors and WS-3 on self-reported relief of withdrawal and craving symptoms associated with use of ONPs. II. Compare demand for ONPs that vary according to menthol flavors and WS-3. OUTLINE: Participants are randomized to sample 4 ONPs in a 1 visit, 4-session, randomized cross-over study. Participants sample four randomly-ordered ONPs with flavors consisting of WS-3 only, menthol only, menthol + WS-3, and no menthol or WS-3 over 10 minutes each, with washout periods of 10 minutes between each ONP use period.