Lead Sponsor

Eastern Switzerland University of Applied Sciences

Collaborators

University of Edinburgh
National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•aged ≥ 18 years
•stable condition \> 3 weeks (e.g. no exacerbations)
•resting SpO2 ≥ 88% and exercise induced hypoxemia defined by a fall in SpO2 by ≥ 4% and/or below 90% during a 6-minute walk test (6MWT)
•informed consent as documented by signature.

•Severe daytime resting hypoxemia (SpO2 \< 88%)
•long-term oxygen therapy
•unstable condition requiring adaptation of pharmacologic and other treatment modalities or requirement of intensive care or relevant severe concomitant disease
•inability to follow the procedures of the study, e.g. due to language problems psychological disorders, neurological or orthopedic problems with walking disability or inability to ride a bicycle
•women who are pregnant or breast feeding
•enrolment in another clinical trial with active treatment.