A Study Evaluating Concurrent Chemoradiotherapy Combined With Dual Immune Checkpoint Blockade for Limited-stage Small Cell Lung Cancer

Exclusion Criteria

• •Concurrent enrolment in another clinical study, unless it is an observational(non-interventional) clinical study;
• •Mixed small cell and non-small cell lung cancer histology;
• •Prior use of anti-PD-1, anti-PD-L1, or anti-CTLA4 antibodies;
• •Recent major surgery within 4 weeks prior to entry into the study (excluding the placement of vascular access;
• •Active or prior documented autoimmune disease within the past 2 years;
• •Active or prior documented inflammatory bowel disease (eg. Crohn's disease, ulcerative colitis);
• •History of primary immunodeficiency;
• •History of organ transplant that requires therapeutic immunosuppression;
• •Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, uncontrolled hypertension, unstable angina pectoris, cardiac arrhythmia, active peptic ulcer disease or gastritis, active bleeding diatheses including any patient known to have hepatitis B, hepatitis C or human immunodeficiency virus (HIV), or psychiatric illness/social situations that would limit compliance with study requirements or compromise the ability of the patient to give written informed consent;
• •Known history of tuberculosis;
• •History of another primary malignancy within 5 years prior to starting treatment, except for adequately treated basal or squamous cell carcinoma of the skin or cancer of the cervix in situ and the disease under study;
• •Female patients who are pregnant, breast-feeding or male or female patients of reproductive potential who are not employing an effective method of birth control.