The Affiliated Hospital of Hangzhou Normal University
Red Cross Hospital, Hangzhou, China
The Third Affiliated hospital of Zhejiang Chinese Medical University
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Aged between 18 and 65 years; both men and women.
Diagnosis of migraine according to the International Classification of Headache Disorders, 3rd edition (ICHD-III), with first onset before age 50 and a history of migraine for more than 1 year.
Migraine frequency of ≥4 days per month during both the 3 months prior to the screening period and the screening period itself.
Informed consent documents are signed, and subjects are cooperative with the evaluation and rTMS treatment, having been informed of known and potential risks and available alternative treatments.
You may not be if
Patients with contraindications to TMS (e.g., metal implants, pacemakers).
Severe anxiety or depression (HAMD score \>35, HAMA score \>29).
History of migraine prophylactic drug adjustment during the screening and treatment period.
Aphasia or cognitive dysfunction (MMSE score ≤23).
Pregnancy or lactation.
Clinicians assess severe comorbidities that are not treatable.
