Comparative Study of Caries-Preventive Effects: 2% Calcium Hypophosphite Toothpaste vs. Sodium Fluoride Toothpaste (1450ppm F)

Exclusion Criteria

• •Untreated caries \[clinical investigation and analysis with an intraoral camera (DIAGNOcam)\] (→ unsuitable subjects with one or two untreated caries in need of a restoration can become eligible after restorative therapy. If there are three or more untreated caries patients will be excluded)
• •Xerostomia (medication, radiation, disease induced)
• •Chemo/radiation therapy
• •Physical or mental disability which prevents proper oral health care
• •Orthodontic treatment
• •Severe periodontitis at the Baseline Visit (pocket depth on at least one tooth ≥ 5.5 mm)
• •Known hypersensitivity to one of the ingredients of the toothpastes to be tested
• •Regular medication intake interfering with salivary function or flow
• •Current pregnancy, the wish to become pregnant, the suspicion of being pregnant, or breastfeeding or in the course of the study
• •3 or more carious lesions/restorations in last 36 months until Baseline Visit
• •Teeth missing due to caries in last 36 months until Baseline Visit