1. Confirmed diagnosis with primary invasive breast cancer.
2. Patients eligible for receiving neoadjuvant chemotherapy.
3. Eastern Cooperative Oncology Group (ECOG) performance status from 0 to 2.
4. Adequate bone marrow function (white blood count ≥4,000/mm3, platelet count≥100,000/mm3), liver function (aspartate aminotransferase and alanine aminotransferase ≤ 2.5times the upper limit of normal, serum total bilirubin \< 1.5 mg/dl), renal function (creatinine \< 1.5 mg/dl)
You may not be if
1. Patients with metastatic or non-invasive disease.
2. Patients previously received chemotherapy within one month preceding randomization.
3. Patients who were previously taking melatonin.
4. Hypersensitivity to melatonin.
5. Patients with autoimmune diseases.
6. Pregnancy and lactation.
Clareo Health | Melatonin in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy
