An Ascending Dose Study of PIT565 in Participants With Rheumatoid Arthritis

Exclusion Criteria

• •Any of the following cardiac conditions
• •1. Unstable angina, myocardial infarction, coronary artery bypass graft (CABG), or stroke within 6 months prior to screening
• •2. Clinically significant and/or uncontrolled heart disease such as congestive heart failure requiring treatment (NYHA Grade ≥ 2) or uncontrolled hypertension
• •3. Concomitant clinically significant cardiac arrhythmias, e.g., sustained ventricular tachycardia, and clinically significant second or third degree atrioventricular block without a pacemaker
• •4. History of familial long QT syndrome or known family history of Torsades-de- Pointes
• •5. Resting QTcF ≥ 450 msec (male) or ≥ 460 msec (female) at screening
• •6. Use of agents known to prolong the QT interval unless they can be permanently discontinued for the duration of the study.