1. Subjects must voluntarily agree to participate in the trial and sign a written informed consent form.

2. Male or female ≥ 18 years old and ≤75 years old.

3. With histologically or cytologically confirmed metastatic pancreatic cancer harboring KRAS G12D mutation

4. Be able to provide tumor tissue samples that meet the requirements

5. Have at least one measurable lesion according to RECIST1.1

6. ECOG performance status of 0-1.

7. With a life expectancy of ≥12 weeks.

8. Adequate laboratory parameters during the screening period.

A Phase II Study to Evaluate GFH375 in Patients With KRAS G12D Mutant Metastatic Pancreatic Cancer