CARAMEL: Retrospective Study for Personalized Risk Assessment of Cardiovascular Disease in Menopausal and Perimenopausal Women Using Real World Data

Inclusion Criteria

• •Self-identified as female in the electronic health record (EHR). Age between 40 and 60 years at the time of data collection/index date. Availability of at least 5-6 years of retrospective data in the EHR, depending on the research objective.
• •At least one healthcare encounter (visit, imaging, lab test, diagnosis, etc.) within the defined age range.
• •For imaging substudies (e.g., RO3-RO5): availability of at least one relevant imaging test (e.g., DXA, digital mammography, cMRI, CCTA, US) during the age range.
• •For signal-based analysis (RO6): presence of ECG monitoring data from implanted devices and at least 2 years of follow-up.