Effectiveness of Personalized Alternating Current Stimulation for Treating Cognitive Impairment in CNS Demyelination Patients

Exclusion Criteria

• •Relapse record within the past month;
• •Medication adjustment within the past month or having undergone modified electroconvulsive therapy, transcranial magnetic stimulation, or other neuromodulation techniques;
• •Participating in any other clinical research within 1 month prior to enrollment or currently;
• •Presence of cochlear hearing aids, cardiac pacemakers, or implanted brain stimulation devices;
• •Skin integrity damage at electrode placement sites, or allergy to electrode gel or adhesives;
• •History of epilepsy, hydrocephalus, central nervous system tumors, brain injury, or intracranial infections;
• •Pregnant or lactating women, or those planning pregnancy in the near future;
• •Scoring ≥3 on item 3 (suicide item) of the HDRS-17 or concurrent severe mental illness;
• •Concurrent severe or unstable organic diseases;
• •Unable to cooperate with treatment, follow-up, or clinical, EEG, and imaging data collection due to poor patient compliance;
• •Other situations deemed inappropriate for study participation by the researchers.