Evaluation of the Effect of Adapted Physical Activity on the Modification of Lipid Metabolism During Chemotherapy for Metastatic COLorectal Cancer

Exclusion Criteria

• •\- Independent physical activity exceeding INCa recommendations: Moderate physical activity greater than or equal to 300 minutes/week (≥5h) or intense physical activity greater than or equal to 150 minutes/week (≥2.5h)).
• •Specific diet and/or any lipid-lowering treatment within 15 days prior to randomisation.
• •Metformin treatment within 15 days prior to randomisation.
• •Any medical conditions or co-morbidities likely to contraindicate the practice of physical activity. The list below is not exhaustive:
• •Previous stroke Myocardial infarction in the 6 months prior to inclusion Uncontrolled arterial hypertension Severe cardiovascular or respiratory disease Rheumatological/orthopaedic conditions or bone lesions at risk of fracture
• •Presence of symptomatic cerebral metastasis(es).
• •Prognosis estimated at less than 3 months.
• •Unable to undergo medical monitoring of the trial and the various visits for geographical, social or psychological reasons.
• •Persons deprived of their liberty or under guardianship (including curatorship).
• •Pregnant or breast-feeding women (pregnancy test compulsory at inclusion).
• •The patient does not have internet access / a smartphone / does not wish to download the AXOMOVE application required to take part in the study.
• •Patients with a history of cancer other than basal cell cancer, or who have already received systemic anti-cancer treatment.
• •Persons with a special diet, metformin treatment and/or any lipid-lowering treatment in the 15 days prior to inclusion.
• •Persons with moderate physical activity exceeding 300 minutes/week or intense physical activity exceeding 150 minutes/week.
• •Persons deprived of their liberty or under guardianship (including curatorship).
• •Pregnant or breast-feeding women (pregnancy test compulsory at inclusion).