Awake Prone Positioning in Spontaneous Breathing Patients With Acute Hypoxic Respiratory Failure Due to Pneumonia

Exclusion Criteria

• •Patients are excluded from the study if any of the following criteria are met at screening or before ran-domization, a detailed list is shown in the study manual:
• •* Age below 18
• •* Pregnant woman
• •* Patient is unlikely/unable to awake prone positioning, or to be compliant as indicated by the treating team
• •* Prolonged need (≥ 4 days) for HFNO, NIV or CPAP before study inclusion
• •* Urgent need for endotracheal intubation
• •* Invasive Mechanical Ventilation
• •* Shock
• •o Defined as need for vasopressor ≥ 0.4 mcg/kg/min to maintain a mean blood pressure of ≥ 65 mmHg or systolic blood pressure ≥ 90 mmHg
• •* Participation in another clinical interventional trial in the last 3 months
• •* Previous Participation in the PROSA Trial
• •* Long-term oxygenation therapy (LTOT) or continuous positive airway pressure (CPAP) therapy before hospital admission
• •* Treatment