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RECRUITINGNANCT06930391

Effect of Extracellular Calcium on Carbetocin Mediated Contractility in Human Myometrium

Postpartum hemorrhage (PPH) continues to be an increasing problem globally. Uterotonics play an essential role in the pharmacological management of uterine atony. Carbetocin, a long acting analog of o...

Lead sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital•1 locations•View source on ClinicalTrials.gov

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Contacts

Mrinalini Balki, MD

CONTACT

416-586-480 [email protected]

Sponsors

Lead Sponsor

Samuel Lunenfeld Research Institute, Mount Sinai Hospital

Age

18 - 40 years

Sex

FEMALE

Healthy Volunteers

Yes

Inclusion Criteria

•non-laboring women with gestational age between 37 to 41 weeks
•not exposed to exogenous oxytocin, scheduled for a primary or first repeat cesarean delivery under neuraxial anesthesia.

Exclusion Criteria

•patients requiring general anesthesia
•more than 1 previous cesarean delivery
•history of uterine atony
•emergency cesarean section in labor
•patients using medications that could affect myometrial contractility such as nifedipine, labetalol, or magnesium sulphate.
•patients with any condition of predisposing to uterine atony and postpartum hemorrhage, such as abnormal placentation, multiple gestation, severe preeclampsia, macrosomia, polyhydroamnios, large uterine fibroids, chorioamnionitis, previous history of postpartum bleeding.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: September 24, 2025Terms

Trial snapshot

StatusRECRUITING

PhaseNA

Enrollment40

Start dateSep 2025

Last updatedSep 24, 2025

Condition

Postpartum Hemorrhage (Primary)

Locations shown

Mount Sinai Hospital

Toronto, Ontario

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 24, 2025Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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