CD7 CAR T-Cell Therapy for r/r T-cell Lymphomas

Exclusion Criteria

• •Patients with history of allogeneic HSCT but PBMNC is not available from prior- transplant donor for preparation of CAR T cells and peripheral blood tumour load \>30%; patients without history of allogeneic HSCT and peripheral blood tumour load \>30%;
• •Intracranial hypertension or cerebral impaired consciousness;
• •Symptomatic heart failure or severe arrhythmia;
• •Symptoms of severe respiratory failure;
• •With other types of malignancy;
• •Diffuse intravascular coagulation;
• •Serum creatinine and/or urea nitrogen ≥ 1.5 times the normal value;
• •With sepsis or other uncontrollable infection;
• •Suffering from uncontrollable diabetes mellitus;
• •Severe mental disorders;
• •Have significant intracranial lesions on cranial MRI;
• •Organ transplantation (excluding haematopoietic stem cell transplantation) history;
• •Female patients (patients of childbearing potential) with positive blood HCG test;
• •Hepatitis (including hepatitis B and C) and positive screening for AIDS and syphilis.