Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

HIV-infected adults aged 18 years or older
Virologically suppressed on ART documented with two negative viral loads separated by at least 6 months
Confirmed diagnosis of immunological failure (CD4+ T cell count \<350 cells/µL 2 years after effective ART initiation)
Willing to provide informed consent

Active opportunistic infections
Known allergies or sensitivities to NMN or any components of the NMN supplement
Current or recent use of other supplements or medications known to affect NAD+ metabolism (Niacin, NR, NMNH, etc.)
Pregnancy or breastfeeding
Significant liver or kidney disease
Active malignancy
History of uncontrolled substance abuse
Severe medical conditions that might interfere with study participation
Unable to consent

Impact of NMN Supplementation on CD4+ T Cell Recovery in HIV Patients With Immunological Failure