A Phase Ib Study of RC148 as Monotherapy or Combination for Locally Advanced or Metastatic NSCLC

Exclusion Criteria

• •1. Histopathologically or cytologically confirmed small cell lung cancer;
• •2. Received major surgeries and still in recovery within 28 days before the first dose;
• •3. Received any live vaccine within 28 days prior to the first dose or plan to be vaccinated during the study (except for COVID-19 vaccine);
• •4. Received immune checkpoint inhibitor (anti-PD-1/PD-L1/CTLA-4 antibody) or other immune checkpoint inhibitor treatment within 28 days prior to the first dose, or experienced prior permanent immunotherapy discontinuation due to immunotoxicity;
• •5. Participated in other clinical trials and received other investigational anti-tumor therapy within 28 days prior to the first dose;
• •6. Poor compliance and unable to complete the study procedures as assessed by investigator;
• •7. Have any other medical conditions, abnormal physical examinations or laboratory examinations that would be suspected interfere with participation or evaluation of the trial or increase the risk to the participant, in view of the investigator.