Karolinska Schizophrenia Project

KaSP aims to recruit 120 patients sparsely medicated or drug-naive first episode psychosis (FEP) individuals, along with 80 healthy controls. Participants undergo the following assessments and measurements: * Clinical assessment * Cognitive testing * Lab results from cerebrospinal fluid, blood, urine, saliva and skin biopsy * Brain imaging using Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) * Pre-Pulse Inhibition (PPI) (a test to evaluate the startle response) * Measures of arterial stiffness and amount of vascular narrowing Participants with psychosis are invited back for repeat measurements at 1,5 and 5 years after study enrollment. Controls may be invited back at 1,5 years for repeat of some of the assessments.