Study of the Link Between MASH ( Metabolic Dysfunction-Associated Steatohepatitis) and MAMs (Mitochondria-Associated Membranes ) Alteration in Patients Undergoing Bariatric Surgery - MAMBA

Exclusion Criteria

• •* Patient presenting Hepatitis B as defined as presence of hepatitis B surface antigen (HBsAg).
• •* Patient presenting previous or current infection with Hepatitis C
• •* Autoimmune hepatitis as defined by anti-nuclear antibody (ANA) of 1:160 or greater and liver histology consistent with autoimmune hepatitis or previous response to immunosuppressive therapy.
• •* Patient presenting Autoimmune cholestatic liver disorders as defined by elevation of alkaline phosphatase and anti-mitochondrial antibody of greater than 1:80 or liver histology consistent with primary biliary cirrhosis or elevation of alkaline phosphatase and liver histology consistent with sclerosing cholangitis.
• •* Patient presenting Wilson disease as defined by ceruloplasmin below the limits of normal and liver histology consistent with Wilson disease.
• •* Patient presenting Alpha-1-antitrypsin deficiency as defined by alpha-1-antitrypsin level less than normal and liver histology consistent with alpha-1-antitrypsin deficiency.
• •* Patient presenting Hemochromatosis as defined by presence of 3+ or 4+ stainable iron on liver biopsy and homozygosity for C282Y or compound heterozygosity for C282Y/H63D.
• •* Patient presenting Drug-induced liver disease as defined on the basis of typical exposure and history.
• •* Patient presenting Bile duct obstruction as shown by imaging studies.
• •* History of ingestion of medications known to produce steatosis, such as corticosteroids, high-dose estrogen, tamoxifen, methotrexate, amiodarone or tetracycline in the previous 6 months.
• •* Evidence of cirrhosis or previously known cirrhosis based on the results from previous liver biopsy or history of portal hypertension presented by ascites, hepatic encephalopathy or varices
• •* Consommation régulière et/ou excessive d'alcool (plus de 30g/j pour les hommes et plus de 15 g/j pour les femmes) sur une période de plus de 2 ans au cours des 10 dernières années.
• •* History of known HIV infection
• •* History of type 1 diabetes
• •* Pregnant women or breastfeeding mothers\*.
• •* Minor patient
• •* Patient deprived of liberty,
• •* Patients under psychiatric care
• •* Patients admitted to a health or social care establishment for purposes other than research
• •* Mentally unbalanced patients, under supervision or guardianship,
• •* Patients not affiliated to a social security scheme or benefiting from a similar scheme
• •* Patient who does not understand French/ is unable to give consent,
• •* Patient already included in a trial who may interfere with the study