Study objective To evaluate the effect of analgesic pathways on rebound pain following ankle fracture surgery. The hypothesis is that the intervention will reduce rebound pain by 50% on a numerical rating scale (0-10).
Methods
Trial design Three-armed randomised control trial.
Participants Inclusion criteria Patients undergoing surgery for ankle fracture ORIF receiving regional anaesthesia for postoperative analgesia.
Exclusion criteria Pain preoperatively of any source requiring analgesic consumption (on more than three occasions) within three months of surgery.
History of chronic pain syndrome. History of peripheral neuropathy. Clinically significant cognitive impairment (MiniMental state score \< 24).
Interventions After giving written consent, patients will be assigned to one of 3 study groups using a random number generator.
All patients will receive standardised single shot ultrasound guided popliteal and sciatic nerve blocks.
Single shot peripheral nerve block standardised protocol 10ml of Bupivacaine 0.5% with 5ml of 2% lignocaine will be used in the popliteal sciatic block and 10ml of Bupivacaine 0.5% with 5ml of 2% lignocaine will be used in the saphenous block.
A lateral approach and subparaneural technique will be applied for the popliteal block at the level of the sciatic nerve bifurcation.
The saphenous block will be administered at the mid-femoral level. For patients who weigh less than 50kg, 10ml of Bupivacaine 0.25% with 5ml of 1% lignocaine will be used in the popliteal sciatic block and 10ml of Bupivacaine 0.25% with 5ml of 1% lignocaine will be used in the saphenous block.
General anaesthesia standardised protocol All patients will have standard monitoring applied intraoperatively. General anaesthesia will be administered using a regimen of intravenous fentanyl 1 mcg/kg, intravenous propofol 2-3 mg/kg and sevoflurane delivered in an oxygen / air mixture, or intravenous fentanyl 1 mcg/kg and total intravenous anaesthesia (TIVA) using a continuous propofol infusion Intravenous ondansetron 4mg, dexamethasone 8 mg, paracetamol 1g, and diclofenac 75 mg will be administered intraoperatively.
Postoperative analgesic plans will differ between groups as follows:
Group C: Postoperative oral analgesia as per current practice standardised protocol Regular paracetamol 1g six-hourly. Ibuprofen 400mg TDS, if not contraindicated. Oxycodone immediate release (Oxynorm) 10mg as required every 4 to 6 hours.
Group TO: timed opioid analgesia protocol Participants will receive single shot peripheral nerve block. Regular paracetamol QDS, regular ibuprofen 400mg TDS, if not contraindicated. Oxycodone immediate release (Oxynorm) 10mg as required every 4 to 6 hours. At 16 hours after block administration: "timed dose"of 10mg Oxynorm to be administered.
Group SC: Sciatic catheter protocol Following administration of the single shot nerve block, a peripheral catheter will be inserted under ultrasound guidance at the level of the sciatic bifurcation.
A continuous infusion of 0.25% bupivacaine at 5ml/hr will be commenced postoperatively on emergence of anaesthesia until 24 hours after PNB administration, at which time the catheter is to be removed.
A standard catheter-through-needle technique will be used for all patients and a regional-specific soft-tipped catheter left in situ with a filter attached. The continuous local anaesthetic will be infused via a standard mechanical wound infiltration pump. This is a 350ml hardshell pump which can provide consistent flow rates. It is non compressible and cannot cause excess dosage due to compression.
Regular paracetamol 1g six-hourly. Ibuprofen 400mg TDS, if not contraindicated. Oxycodone immediate release (Oxynorm) 10mg as required every 4 to 6 hours for breakthrough pain
Follow-up Patients will record changes in pain scores on diary sheets. Total PRN analgesia administered will be recorded from the bedside drug chart and patient pain diary.
QoR9 Questionnaire will be completed on ward or by telephone on Day 1 and Day 2 post-op.
On the same telephone call, participants will be asked to state peak pain score experienced in preceding 24 hours and will be asked to post back pain diaries.
Group SC will receive an information sheet about peripheral nerve block catheter care prior to discharge. The sheet will include contact details for the Regional Anaesthesia Fellow and Anaesthetics Senior Reg, should participants have any queries.
For Group SC, any catheter complications experienced will be recorded at 24 and 48 hours on ward/ by telephone.
Complications:
Catheter falling out \<24 hours New swelling along the catheter track New tenderness around the catheter site New redness around the catheter site Block effects lasting more than 72 hours after removal of catheter New onset of weakness/ numbness 24 hours after the original block wears off If the entire catheter is not removed Outcomes
Primary outcome:
Median peak pain score in 24 hours after PNB administration.
Secondary outcomes:
Time of peak pain occurrence. Impact of intervention on quality of recovery. Defined population at highest risk of rebound pain.
Randomisation After giving written consent, patients will be assigned to one of 3 study groups using a random number generator.
Sample size Our data will be analysed using the ANOVA test to compare mean pain scores between groups. We will power our study to 95% and will set the significance level at 0.05. We hypothesise that our effect size will be 50%. This results in a required sample size of 22 patients in each arm. To allow for participants discontinuing enrolment and not responding to 24 and 48 hour follow-up we will enrol 37 patients in each arm of the study. Our total sample size will be 111.
