Treosulfan Therapeutic Drug Monitoring in Pediatric Hematopoietic Stem Cell Transplant Recipients

Exclusion Criteria

• •Absence of written informed consent signed by the parents or guardians.
• •Current clinically active infectious disease (including positive HIV serology or viral RNA).
• •Severe cardiovascular disease (arrhythmias requiring chronic treatment, congestive heart failure or left ventricular ejection fraction \<40%).
• •Liver dysfunction (AST/ALT ≥ 3 times institutional upper limit normal value -ULN- or bilirubin \> 3 times ULN).
• •Renal dysfunction: serum creatinine \> 1.5 times ULN or calculated creatinine clearance \< 60 ml/min/1.73 m2
• •End stage irreversible multi-system organ failure.
• •Pregnant or breast feeding female patient.