A Study to Identify an Optimal Dose of QCZ484 in Mild to Moderate Hypertensive Patients

Exclusion Criteria

• •1. Known history of secondary hypertension.
• •2. Orthostatic hypotension.
• •3. Laboratory parameter assessments outside of range at screening.
• •4. Evidence of hepatic disease.
• •5. Medical condition, other than hypertension, requiring treatment with RAAS inhibitor.
• •6. Any history of congestive heart failure.
• •7. Current or history of intolerance to ACEi and/or ARBs.
• •8. Clinically significant cardiac arrhythmias, high-grade AV block and third-degree AV block within 6 months prior to screening.
• •9. Acute myocardial infarction (AMI) or unstable angina, or any percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) within 12 months prior to screening. Any history of ischemic or hemorrhagic stroke or transient ischemic attack any time prior to screening.