Effect of Acute Hypoxia on Renal Hemodynamic in Healthy Volunteers, Patients With Diabetes and Patients With Diabetes and Kidney Disease

Exclusion Criteria

• •For all participants:
• •1. Active smoking
• •2. Contraindication to any of the agent (PAH, or iohexol or gadolinium) used in the study.
• •3. Contraindication to cardiac MRI, renal MRI, respiratory tests,
• •4. History acute coronary syndrome or coronary revascularization
• •5. Recent (\<6 months) history of: Heart failure requiring hospitalisation or Stroke or transient ischemic neurologic disorder
• •6. Severe unstable hypertension (≥180 mmHg systolic or ≥110 mmHg diastolic blood pressure)
• •7. Resting oxygen saturation \<95% at baseline
• •8. Any concomitant disease or condition that may interfere with the safety or the possibility for the patient to comply with or complete the study protocol.
• •9. History of severe mountain sickness (dizziness, headache, nausea/vomiting and incapaciting fatigue)
• •10. Consumption of SGLT2 inhibitors
• •11. Concurrent participation in another clinical research study
• •12. Pregnant or breastfeeding women, women of childbearing age who do not have effective contraception
• •13. Persons benefiting from enhanced protection under french national law
• •14. Persons under psychiatric care who are unable to give their consent