CKD stage G3 (creatinine-based eGFR 30-59 mL/min/1.73m2) during the last outpatient visit
eGFR within the expected range for age (a decline of 1 ml/min/1.73 m2 per year starting from age 40 is considered the normal age-related decline in kidney function
You may not be if
Known intolerance or allergy to the diuretics
Current systemic chemotherapy for malignancy
Kidney transplant recipient
Use of calcineurin-inhibitors
Life expectancy \< 12 months
Current immunosuppressive treatment for glomerulonephritis
Incapacitated subjects or subjects who are deemed unfit to adequately adhere to instructions from the research team
Hypokalemia or hyperkalemia (K+ \< 3.0mmol/L or K+ \> 5.5 mmol/L) at inclusion visit
Hypo- or hypernatremia (Na+ \< 130 mmol/L or Na+ \> 150mmol/L) at inclusion visit
Inherited tubulopathy as the cause of CKD
Autosomal dominant polycystic or tubulointerstitial kidney disease causing CKD
Clinically relevant heart failure (New York Heart Association class III or IV)
Therapy-resistant hypertension, defined as systolic blood pressure \> 180mmHg at the inclusion visit
Current treatment with inhibitors of Organic anion transporters: probenecid, pravastatin, cimetidine, cephalosporins, acetazolamide \[22\]
Active hepatitis during last outpatient visit
Liver cirrhosis in advanced stage (Child-Pugh B or C)
Active drug- or alcohol abuse
Not being able to tolerate a 28-day washout of one of the drugs interfering with diuretic testing.
Women who are pregnant, breastfeeding, or planning on becoming pregnant before the test day
