Validation of Nanosensor Oxygen Measurement

Exclusion Criteria

• •Subjects will be excluded if any of the following apply:
• •1. Unable to provide informed consent and complete all study procedures, including ergometry
• •2. Non-ambulatory or unable to ambulate independently
• •3. Pregnant
• •4. Within 1 month of a recent hospital admission due to acute illness
• •5. Have severe cardiac disease as defined by an ejection fraction of less than 35% and New York Heart Association Functional Classification Class III; or severe pulmonary disease as defined by the need for supplemental O2 therapy or daytime ventilatory support
• •6. Have a tracheostomy
• •7. Have a known bleeding disorder and/or family history (first-degree relative) with a known bleeding disorder
• •8. Daily intake of aspirin or any other anti-platelet therapy which cannot be temporarily discontinued for medical reasons
• •9. a) Have known or suspected congenital or acquired immune deficiency; b) concurrent use of immunosuppressive drugs, including corticosteroids; c) past history of recurrent (more than 6 times per year) severe (required hospitalization) skin or soft tissue infections; d) history of infection or delayed wound healing after surgery or biopsy; e) known history of neutropenia with absolute neutrophil count less than 500/mm3
• •10. Undergo chronic steroid treatment as defined by daily oral intake (for more than 1 month) or have existing untreated endocrinopathies, such as hypothyroidism that caused acquired myopathy
• •11. Prone to hypertrophic scars and keloids
• •12. Have any other known inherited myopathy, such as Duchenne muscular dystrophy or congenital myopathy
• •13. Known allergy to lidocaine
• •14. Have a cognitive impairment that may prevent the ability to complete study procedures
• •15. Unable to comply with the requirements of the study protocol and/or unsuitable for the study for any reason, in the opinion of the principal investigator
• •16. Individuals from vulnerable populations (e.g., prisoners/detainees)
• •17. Participants who are unable to speak and/or read English (as participants will be required to be proficient to complete study procedures)
• •18. Employed by the U.S. Department of Defense, including U.S. military personnel