Immunological Reset to Allow Access to HLA Compatible Transplantation in Highly Sensitized Kidney Transplant Candidates Through Non-myeloablative Autologous Stemm Cell Transplantation

Exclusion Criteria

• •1. Current known infection, recurrent bacteria, virus, fungus or fungus bacteria, or other infections (such as HIV, hepatitis B, hepatitis C, or zoster).
• •2. Concomitant serious uncontrolled major organ disease.
• •3. Any infection that requires hospitalization and intravenous treatment with antibiotics during the 4 weeks prior to screening, or oral treatment with antibiotics the previous 2 weeks.
• •4. Patients with primary or secondary immunodeficiencies.
• •5. Patient with an active history of tuberculosis (even if treated) or patients with untreated latent tuberculosis.
• •6. Malignancy during the 5 years prior to screening, except for carcinoma of the basal cell or squamous cell carcinoma properly removed.
• •7. Known abuse of alcohol, drugs or chemicals within 1 year prior to screening.
• •8. Patients with complicated peripheral venous access
• •9. Neutropenia (ANC \<1000/uL) or thrombocytopenia (platelet count \<100,000/uL) during the 4 weeks prior to screening.
• •10. Severe allergic or anaphylactic reactions to human monoclonal antibodies, humanized or murine.
• •11. Treatment with any investigational agent during the 4 weeks (or 5 half-lives of the investigational drug, whichever is longer) prior to screening.
• •12. Immunization with live vaccine during the 2 months prior to screening.
• •13. Pregnant or breastfeeding women.