A Study of BBT001 in Healthy Volunteers (HVs) and in Adult Patients With Atopic Dermatitis (AD)

Exclusion Criteria

• •1. Significant health issues, such as: diabetes, positive tests for human immunodeficiency virus (HIV), hepatitis C virus (HCV), or hepatitis B surface antigen (HBsAg), immunodeficiencies, autoimmune diseases, or cancer, history of conditions predisposing to infections.
• •2. History of major metabolic, dermatological, liver, kidney, hematological, or other significant disorders.
• •3. Clinically relevant abnormal lab results, including low blood counts, liver issues, or abnormal kidney function.
• •4. Positive drug/alcohol tests or abnormal vital signs at screening or Day -1.
• •5. Abnormal Electrocardiogram (ECG) findings
• •6. History of drug/alcohol abuse in the past 2 years.
• •7. Donated \>500mL blood within 2 months of screening.
• •8. History of severe allergic reactions or hypersensitivity.
• •1. Skin diseases other than atopic dermatitis, significant tattoos, or scarring.
• •2. Receipt of immunoglobulin or blood products within 30 days.
• •3. Atopic dermatitis with ocular symptoms or chronic ocular steroid use.
• •4. Chronic pruritus from conditions other than atopic dermatitis.
• •5. Acute/treated infections or chronic skin infections.
• •6. Current use of sedating antihistamines or corticosteroids.